From 2 December, William Hill will leave 13 countries across Africa and Asia.
Players in those nations have been notified that, from that date, they will cease to be able to participate in any of the Evoke-owned brand's offerings or services.
The decision follows previous exits in September from India, Jamaica and Botswana.
Markets affected include: Angola, Bolivia, Burkina Faso, Cameroon, Kenya, Mozambique, Nepal, Nicaragua, Nigeria, Republic of Congo, Democratic Republic of Congo, Somalia and Vietnam.
Despite all bets being rendered void from 2 December, players will still be able to access their accounts until 5 January 2026 to withdraw funds.
There is a caveat that any current bets due to be settled after 2 December will now be voided, with any wager returned to bettor's account.
William Hill's business outside of Britain is entirely online, but pressures imparted by the threat of tax rises in next week's Autumn Budget have left the company fearing for its overall profitability.
Evoke has indicated that if proposed tax hikes were confirmed in the Chancellor's 26 November statement, it may be forced to close between 120 and 200 betting shops in the UK.
More positively, Evoke posted third-quarter revenue of £435m ($580m), representing a 5% year-on-year increase across all three divisions: online, international and retail.
Nonetheless, the long-standing UK brand looks to be consolidating its efforts with these exits, and will perhaps focus on shoring up profitability in its core markets.
Evoke recently held a charity gala and raised £153,000 for the Motor Neurone Disease Association
